Effect of Pterocarpus Marsupium in Streptozotocin-induced Hyperglycemic State in Rats: Comparison with Glibenclamide
نویسندگان
چکیده
Pterocarpus marsupium (Family: Leguminoceae) is widely used in ‘Ayurveda’ as ‘Rasayana’ for the management of various metabolic disorders including hyperglycemia. Treatment of diabetic rats with Pterocarpus marsupium methanol extract (PMMtE, 300 mg/kg b.w./day) for 7 and 14 days showed normalization of streptozotocin-distressed serum glucose. At longer duration, PMMtE exerted a protective effect by correcting glycosylated hemoglobin (HbA1c), serum protein, insulin, alkaline and acid phosphatase (ALP and ACP), and albumin levels. Furthermore, tissue biochemical parameters viz. protein and glycogen altered towards normal in comparison to diabetic group. These results suggest oral administration of Pterocarpus marsupium may have the ability to improve streptozotocin-induced chronic diabetic stress. INTRODUCTION
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